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Suzuki, Y., Sa, Q., Gehman, M

[181] demonstrated that low levels of Zn in plasma predispose a person to ventilator-induced injury in intensive care because Zn is related to the role of the MT system in lung protection

Small molecule inhibitors as tools to scan for active pathways do not conclusively rule out the participation of a signaling mediator if a negative result is obtained (i.e., no inhibition/augmentation of a toxic endpoint)