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10.1053/j.gastro.2016.03.038 55
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Conditions for which this effect has been demonstrated are: glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency.7,8 Autointoxication occurs in these patients due to the accumulation of acylCoA compounds that disrupt intermediary metabolism
Even in patients with a prior history of pancreatitis, newer data suggest that GLP-1 RAs are not automatically contraindicated, with recurrence rates comparable to or lower than those seen with other treatments
The challenge is designing a single small molecule with the right binding affinity for both receptors while maintaining favorable pharmacokinetic properties for oral delivery
