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Loss of PINK1 impairs stress-induced autophagy and cell survival
MS2 analysis consisted of quadrupole isolation (isolation window 0.7) of precursor ion followed by collision-induced dissociation (CID) in the ion trap (AGC 1.8E4, normalized collision energy 35%, maximum injection time 120 ms)
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Contributes to the prevention of premature signs of aging
A protocol of alternate-day fasting (ADF, 24 months) in rats was able to reduce oxidative stress (assessed by the increased level of glutathione) and decrease inflammatory status in the heart during aging similar to young animals (Castello et al., 2010)
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