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Procedure day: Report to outpatient surgery if harvesting your own STEM cells via BMAC Anesthesia will be required, typically sedation with monitered anesthesia care but may vary Local anesthesia for comfort Your bone marrow aspirate is surgically harvested from the same involved lower extremity Bone marrow aspirate is spun and concentrated for potent stem cells and platelet rich plasma Image-guided injection into affected area Recovery: Rest and elevation for 48-72 hours Gradual return to activity over 4-6 weeks Full healing response develops over 3-6 months Follow-up appointments at 6 weeks, 3 months, and 6 months Success Rate: Clinical studies show 70-82% of patients with ankle osteoarthritis report significant pain reduction and improved function 6 months post-treatment

So, Let's back up a little bit and talk about the Melanocortin system, right

Carter-Su, C., Schwartz, J., & Argetsinger, L

May support slow-wave and REM sleep architecture, per a placebo-controlled polysomnography study in younger and older adults (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)