PRKCSH encodes for a protein called hepatocystin or 80K-H, which is a beta subunit of glucosidase II 26 and substrate for protein kinase C 26 , that plays a key role in GLUT4 vesicle trafficking (translocation of GLUT4 to the plasma membrane) in the insulin signaling pathway 72 by forming a complex with 80K-H Overexpression of the hepatocystin 1 week after 4-week intermittent fasting is suggestive of improvement of insulin signaling through enhancement of GLUT4 vesicle trafficking
Rather than following restrictive diets, patients are encouraged to adopt realistic eating habits that support long-term success
Was the study conducted in humans
Abbreviations T2D: Type 2 diabetes GLP-1: RA glucagon-like peptide 1 receptor agonist NAFLD: Nonalcoholic fatty liver disease NASH: Nonalcoholic steatohepatitis HCC: Hepatocellular carcinoma HBV: Hepatitis B virus HCV: Hepatitis C virus SGLT2: Sodium-glucose cotransporter 2 References Powell EE, Wong VW, Rinella M
Less common but important adverse effects include pancreatitis (inflammation of the pancreas), which presents with severe, persistent abdominal pain radiating to the back
