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Side Effects at Higher Doses GLP-1 receptor agonists may cause gastrointestinal symptoms such as: Nausea Vomiting Diarrhea Constipation Decreased appetite These effects are often more common as doses increase
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But where semaglutide acts on one receptor (the glucagon-like peptide-1, or GLP-1, receptor), and tirzepatide on two (GLP-1 and the gastric inhibitory polypeptide, or GIP, receptors), retatrutide has been nicknamed Triple G for its ability to work on three hormone receptors (those for GLP-1 and GIP, as well as the glucagon, or GCG, receptor)
Initiation Tirzepatide should be initiated at a dose of 2.5 mg weekly and then increased to 5 mg weekly after four weeks