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Furthermore, GLP-1 RAs exhibit vasodilatory effects by promoting endothelial nitric oxide (NO) synthesis, enhancing endothelial function with a consequent reduction of vascular resistance and an improvement in cardiac afterload [45, 46]
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These could indicate serious complications such as pancreatitis or acute kidney injury, though such occurrences are uncommon during the initial low-dose phase
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Staying within guideline-recommended dosing is one of the best ways to reduce risk. Formulation matters. Extended-release (XL) formulations have a lower seizure risk than immediate-release formulations when used appropriately
