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The C-terminal ~10 amino acids of CT-family peptides, including CT, rAmy, and Cagri, bind to the same groove within the ECD of their cognate receptors (Fig
For pigment specifically, a randomized, vehicle-controlled trial found topical tretinoin significantly improved melasma (a randomized vehicle-controlled trial showing topical tretinoin improves melasma), and a separate vehicle-controlled study confirmed the benefit specifically in patients with darker skin (a vehicle-controlled trial of topical tretinoin for melasma in darker skin)
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