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As of 2025, retatrutide remains under clinical investigation and has not received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for routine clinical use in the UK

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This peptide has been found to facilitate the healing of various tissues, including bones, muscles, and tendons

Zepbound may cause tumors in the thyroid, including thyroid cancer

In the U.S., food companies also face the quickly approaching compliance deadline for the FDAs Food Safety Modernization Act, Rule 204 (the Food Traceability Rule) in January 2026