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Women should be aware that PT-141 may temporarily raise blood pressure and increase heart rate

Given that EASD/ADA guidelines generally suggest GLP-1RAs are more active against atherosclerotic disease than SGLT-2i, the finding of a lower 3-P MACE among new users of SGLT2i versus new users of GLP-1RAs was unexpected and identifies an area where RWS and RCTs are not consistent

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But GLP-1 receptor agonists exploded in popularity after researchers noticed people on the medications had lost significant amounts of weight

Additionally, it has beneficial effects on patients glycemic and blood pressure control, serum high-sensitivity C-reactive protein (hs-CRP) levels, total cholesterol/HDL cholesterol ratio, total cholesterol, and mental health parameters [209]