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Hoyles L, Pontifex MG, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, et al
Nourishing Your Skin: Your skin, being the bodys largest organ, requires special attention
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A 2025 narrative review published on PMC confirmed that oral glutathione shows significant, if variable, reductions in melanin levels with limited side effects, with the 500 mg per day dose consistently cited as effective
Untargeted metabolomic analysis Metabolomic sequencing of serum was performed as described previously [24], and untargeted metabolomic analysis of the NC and PD groups was performed by LCMS/MS, which was performed on a quadrupole electrostatic field Orbitrap high-resolution mass spectrometer
Clinical evaluation of melasma At the end of treatment period, hemi-MASI score was not significantly decreased on both right side (Glutathione gel treated side) ( P value = 0.1), and left side (Placebo treated side) ( P value = 0.3), with no significant difference between them ( P value=0.2) (Table 2)
