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Carnitine is found almost exclusively (99%) intracellularly, existing either as free LC or as several species of acyl-carnitine esters, predominantly in the muscle and liver
In this context, pharmacological modulation of energy homeostasis pathways may exert pleiotropic effects, including body mass reduction accompanied by decreased bone density, interference with neuronal and adipogenic precursor differentiation, and epigenetic modifications with potential transgenerational impact
For GLP-1 antagonist treatment, mice were injected with exendin-(939) amide (Ex-9) (2081, R&D Systems) at a dose of 25 nmol/kg/day or vehicle (PBS) for 5 days
But injectable GLP-1s like Wegovy and Zepbound may lead to greater overall weight loss