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A double-blind, placebo-controlled Phase 2b RCT (NCT03235752) was completed in December 2020 and enrolled 91 adults with active UC across 22 clinical sites in East Asia, comparing biweekly intravenous infusions of olamkicept 600 mg or 300 mg versus placebo over 12 weeks, with the primary endpoint being clinical response defined as a decrease of 3 or greater and 30% or greater from baseline total MS plus at least 1-point reduction in RBS (64)