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In DFU, notch pathway dysfunction can lead to inhibition of cell differentiation, proliferation disorders, and reduced angiogenesis, all of which interfere with diabetic wound healing

198 The system with low immunogenicity and systemic toxicity improved blood cycle time and tumor accumulation in U87MG glioblastoma tumor-bearing nude mice

10.3810/pgm.2013.05.2659 123

The amygdala, a brain region involved in emotion and behavior regulation, appears to be the site of this action, highlighting the complexity of neural pathways involved in regulating alcohol consumption