Short-term oral alpha-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men
Indeed, several small-molecule GST inhibitors have been reported as anticancer agents 4
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Targeting this system, either by hepatocyte-specific knockout of peroxisomes or by deficiency in ACOX (which catalyzes the initial step in peroxisomal FAO), results in hepatic lipid accumulation and fibrosis, oxidative stress, and inflammation, emphasizing the role of peroximal FAO in NAFLD and NASH [108]
Participating in glutathione binding reactions as a transferase, GST is widely dispersed across the cytoplasm of various cell types, acting as a critical component in the metabolism of numerous intrinsic and extrinsic toxins