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Furthermore, the included studies were heterogeneous concerning the characteristics of patients and study design (2 of studies on L-carnitine supplementation have been performed in the setting of hemodialysis when carnitine metabolism is altered in uremia and the depletion of carnitine is expected 62 , 4 in diabetic/metabolic syndrome patients with dyslipidemia and 1 in hyperlipidemic patients)

Pattern recognition receptors and inflammation

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+ The most common area is the submental fat under the chin