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J Formosan Med Assoc (2019) 118:S4254

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It significantly diverges from conventional pathways of cell death (such as apoptosis and autophagy) and was initially reported and elucidated by Dixon et al

Over the following weeks most people notice better sleep and a small energy lift first (weeks 12), then a looser waistband and faster recovery (weeks 24), then measurable belly-fat reduction and visible body-composition change (weeks 48), with the strongest results from week 8 onward

Its half-life is short (7 minutes) because it is rapidly cleaved by dipeptidyl peptidase-IV (DPP-IV) after residues 2-3