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The fact that high levels of GST are associated with resistance to apoptosis induced by a range of substances, including chemotherapeutic agents, supports its putative role in MAPK signaling prevention
312 Similarly, EMT contributes to oxaliplatin and cisplatin resistance in gastric and colorectal cancers, mediated by factors such as Rab31 (via the Stat3/MUC-1/Twist1 axis) and THBS2 CAFs (via COL8A1-driven PI3K/AKT signaling)
The cardioprotective properties, weight loss, and blood glucose control can be significant
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