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Structure-based rational design of novel inhibitors against fructose-1,6-bisphosphate aldolase from candida albicans

Tolerability relative to insulin tolerance testing

The 4 mg arm landed near the territory that semaglutide occupies, the 8 mg arm matched what tirzepatide achieves at its top dose, and the 12 mg arm went somewhere no single or dual agonist had reached in a trial of that size