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Upregulation of the PD-L1/PD-1 axis induces T cell exhaustion, while the expression of dont eat me signals, such as CD47 (interacting with SIRP) and CD24 (interacting with Siglec-10), prevents macrophage-mediated phagocytosis
This approach simplifies administration while capturing the synergistic benefits of all three compounds
We adjust the dose to how youre responding rather than raising it on a fixed schedule
L.OppoV.FabbriM.SarchiotoM.et al
Thus, meticulousness is critical
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