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Front Endocrinol 11:102 Qian Y, He L, Su A, Hu Y, Zhu J (2023) Generation of a mouse spontaneous autoimmune thyroiditis model

Since the replacement of Gly with basic d-Arg in position 6 caused the local anaphylactoid reaction, new analogs with neutral d-ureidoalkyl amino acids, such as d-citruline at position 6were synthesized by our group 20

* Feeling of incomplete bowel emptying

The two approaches answer different research questions