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Tirzepatide was started at 2.5 mg once weekly and escalated following the standard 4-week titration schedule

(2001) demonstrated significant linkage at marker D6S264 (LOD score 3.45), with fine-mapping in a 3,400-member Swedish pedigree revealing a haplotype in 6q25 that segregates with affected individuals, suggesting that this region may harbor susceptibility variants related to PDE signaling (Loughney et al., 1999

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These findings support continued clinical evaluation of AMG 133