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Highlights from the July 2024 study include: Our main finding is that prescribed semaglutide is associated with an increased risk of NAION. Patients with diabetes who took semaglutide were more than four times more likely to develop NAION than those on other medications

A 2025 preprint showed semaglutide users were about 50% more likely to receive a hair-loss diagnosis than users of Contrave again pointing to an indirect mechanism

Accelerated clearance of Plasmodium -infected erythrocytes in sickle cell trait and annexin-A7 deficiency

While some medications wont substantially impact semaglutide, the weight loss medicine may affect other prescription medications, including those that treat thyroid conditions, those that contain insulin, and sulfonylureas

Another study assessed 524, 510, and 40 spontaneous reports of pancreatitis from the FDA Adverse Event Reporting System (FAERS) database, VigiBase, and CARD databases, respectively, to determine the potential association between SGLT2 inhibitors and pancreatitis