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Intervention with ferroptosis inhibitors such as ferrostatin-1 and deferoxamine has been shown to restore chondrocyte viability, reduce MMP13 and ADAMTS5 expression, and partially rescue extracellular matrix loss, suggesting that inhibiting ferroptosis may mitigate OA cartilage injury (54, 55)
In addition to stability and delivery challenges, peptides, particularly those derived from non-human sources, carry the risk of triggering immune responses
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HDL first bind to SR-BI and then the cholesteryl esters present in the HDL are transferred to the membrane for uptake via caveolae
For the fungus (Candida glabrata and Candida Parapsilosis), glutathione is also a virulence factor, helping the yeast resist oxidative stress and antifungal drugs
