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PCD currently includes apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and cuproptosis (Mishra et al., 2018)
These receptors share a common activation mechanism where the C-terminus of the cognate ligand is initially recognized by the receptor via an N-terminal extracellular domain that forms a hydrophobic ligand-binding groove [5]
Spillantini MG, Schmidt ML, Lee VM-Y, et al
m: potencial de membrana mitocondrial
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