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Unexpectedly, we found that GLP-1 WT bound human FcRn 5-fold more strongly than unfused WT albumin at acidic pH, due to both faster association and slower dissociation

Common diagnoses include: Type 2 diabetes Obesity (generally a BMI of 30 or higher) Overweight (BMI of 27 or higher) when combined with a related health condition such as high blood pressure, high cholesterol, sleep apnea, or insulin resistance Some GLP-1 medications approved for diabetes are often prescribed off-label for weight loss

Annu Rev Pathol 11:451496

Presented for research literature review only Sizova ZM et al