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The evidence from both protective and at-risk IFIH1 variants highlights the critical role of the type I IFN pathway in T1D pathogenesis

Lab protocols should address potential exposure risks and implement appropriate containment measures

Biochem Biophys Res Commun 524(2):385391 Paik S, Kim JK, Silwal P, Sasakawa C, Jo EK (2021) An update on the regulatory mechanisms of NLRP3 inflammasome activation

The NICE recommendations tell GPs to consider testing in anyone with one symptom or one risk factor, and to treat early to prevent neurological damage that can become permanent

Some laboratories are even developing intelligent formulas capable of targeting only hyperactive melanocytes, leaving natural pigmentation intact