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The pathway is sometimes referred to as a cycle, but according to its classical representation, it is a linear sequence that links reduction of H 2 O 2 , catalysed by APX, to oxidation of NADH or NADPH, catalysed by MDHAR and GR (Fig
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Both BPTES and 968 were reported to be having low micromolar potency and chemical modification may be need for improvement [60]