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Higher sensitivity to sweet and salty taste in obese compared to lean individuals
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Biochemically, DSIP constitutes 9 amino acids with the following sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and is known to easily cross the blood-brain barrier to initiate its sleep onset mechanism
Critically, this effect is glucose-dependent, meaning insulin secretion diminishes as blood glucose normalizes, substantially reducing hypoglycemia risk compared to sulfonylureas or exogenous insulin
doi: 10.1093/ajcn/82.1.230S
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