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9 Proposed activation mechanism of class B GPCRs
Breaking this cycle requires interventions at multiple points: suppressing the aberrant immune response, protecting oligodendrocytes from ongoing damage, promoting remyelination of denuded axons, and reducing the oxidative stress and neuroinflammation that perpetuate the process
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Where it holds, it matters for exploratory work where the goal is a preliminary signal rather than a definitive result
References Bloem BR, Okun MS, Klein C (2021) Parkinsons disease
