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Demonstrated positive response defined as 5% reduction from baseline body weight (adults) or baseline BMI (pediatrics), or maintenance of weight loss with continued participation in a weight management program that includes lifestyle modification, exercise, and reduced calorie diet
C.MeiklejohnJ.BrodatyH.et al (2014)
Cumulative melanocortin exposure (total dose across protocol duration) predicts endpoint pigmentation more accurately than peak daily dose
This means they do not require a prescription for purchase, but it also means supplements may vary in quality and standardisation between manufacturers
"Safety and efficacy of liraglutide 3.0 mg for weight management: a meta-analysis of randomized controlled trials." Clinical Obesity
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