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When the storage capacity is exceeded, accumulated cholesterol crystallizes, leading to hepatocyte apoptosis and the release of cholesterol-crystal-laden lipid droplets (53)
This process involves large-scale studies that evaluate the drug's effects on a diverse population, identifying potential side effects and establishing appropriate dosing guidelines
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Nat Med 15:629632 Singh S, Padovani D, Leslie RA, Chiku T, Banerjee R (2009) Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H 2 S biogenesis via alternative trans-sulfuration reactions
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