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Identification of coenzyme A-related tolmetin metabolites in rats: relationship with reactive drug metabolites

Then, we evaluated L-carnitine-attributed effects by comparing VPA elimination half-lives and time-courses of blood lactate levels and organ dysfunction [assessed by the Sequential Organ Failure Assessment (SOFA) score] between matched L-carnitine-treated and non-treated patients using a multivariate analysis including a propensity score

Hemocompatibility tests were conducted to evaluate safety

Despite compelling preclinical data, clinical translation remains challenging issues, such as patient stratification, identification of predictive biomarkers and optimization of controlled release kinetics must be addressed

PMID: 104 SchauerSNGuillaumeDDecourtCWatsonEDBriantCDonadeuFX