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It should be noted that physiologic GLP-1R agonism in the periphery mediates food intake reduction via vagal afferent signaling as rats with a surgical subdiaphragmatic vagal deafferentation (SDA) exhibit a more mild food intake suppression in response to acute administration of GLP-1 analogues than sham operated animals (80, 81)
Armstrong MJ, Hull D, Guo K, Barton D, Hazlehurst JM, Gathercole LL, et al
Therefore, therapeutic choices should reflect both anticipated weight reduction and compound-specific benefits
Whether youre using a GLP-1 medication or following a calorie deficit, its essential to protect your muscle mass so the weight you lose comes primarily from body fat, not muscle
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