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The degree of phase II conjugation, typically encompassing sulfation, glucuronidation and methylation (see section 6.1 Pre-systemic metabolism: role of gut microbiota), is high for individual molecules (Table 3)

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Blood samples were taken at the following times in relation to dosing: Predose (day 0) for all 4 groups then 5 min, 6 h, 1, 3, 5, 6, 7, 8, 9, 10, 12 and 30 days for the 1 mg/kg (i.v.) group

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