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Second, and this is just as important, the cold environment itself creates a hostile setting for any potential microbial contaminants that might have been introduced

Diabetologia 45 , 195202 (2002)

[4] Dehkordi SR, et al

The initiation of an SGLT2 inhibitor may well take place in the context of a specialist HF clinic, but could reasonably be undertaken in primary care where there is experience with the use of SGLT2 inhibitors and management of HF