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Figure from van der Aart-van der Beek AB, Nat Rev Nephrol, 2020 The Study Methods This was an international, event-driven, double-blind, parallel-group, randomized, placebo-controlled trial conducted at 387 sites in 28 countries comparing semaglutide to placebo in patients with T2DM and CKD, both being treated with baseline standard of care
Med Hypotheses 143 , 110185 (2020)
Passed: Confirms active ingredient concentration is within 10% of the label claim
Drucker suspects, however, that it has to do with semaglutides ability to circulate longer in the body without degrading, possibly combined with an ability to bind to the GLP-1 receptor more strongly than older drugs
Cell culture Cell lines were maintained in RPMI 1640 (Thermo Fisher, 11875119) with 5% FBS (Sigma-Aldrich, SH30396.03) and 1% penicillin and streptomycin (Thermo Fisher, 15070063)
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