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Clinical trials show gastrointestinal side effects (nausea, vomiting, constipation) affect 20-40% of users across semaglutide, tirzepatide, and retatrutide, but severity and persistence vary widely
Starting naltrexone while opioids are still in your system can trigger sudden withdrawal symptoms, which may require medical care
doi:10.1210/jcem.87.4.8421 Guilliams TG, Drake LE
Next Steps: What to Do If You Qualify for Coverage If your insurance covers a GLP-1 medication, let your healthcare provider know
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