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Fitz, V., Graca, S., Mahalingaiah, S., Liu, J., Lai, L., Butt, A., Armour, M., Rao, V., Naidoo, D., Maunder, A., et al
SHANK3 mutations impair mGluR-dependent LTD and attenuate the ability of hippocampal neurons to express group I metabotropic mGluRs at synapses [59]
doi: 10.1155/2011/407031 106 KassanSSMoutsopoulosHM
Specifically, berberine can cause: Nausea Diarrhea Stomach cramps Bloating Headache Constipation (particularly when you stop taking it) Rashes (though this is relatively rare) The more berberine you take, the more likely you are to experience these side effects
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