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Supports mood, immunity, tissue health, enzyme function, and overall wellness

These outcomes were further endorsed by the recent ESC Clinical Consensus Statement on Obesity and Cardiovascular Disease (87)

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For example, the deregulation of the insulin and insulin-like growth factor (IIS) pathway is common with aging

The overall heterogeneity levels were 24.4% (95% uncertainty intervals, 0 and 54.9%) for nonfatal MI (moderate), 11.1% (95% uncertainty intervals, 0 and 48.0%) for nonfatal stroke (low) and 15.8% (95% uncertainty intervals, 0 and 49.9%) for CV death (moderate) (Additional file 1: Table S3)