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Prog Neuro-Psychopharmacology Biol Psychiatry 35:19441949
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The hydrogen bonding network stabilize the adduct complex to a greater extent, making the binding between drug and protein stronger and hence increases the binding as compared to gas phase adduct
Factors conferring relative protection to children from the toxic effect of paracetamol overdose include increases in paracetamol sulphation capacity [44,45,46,47,48], relative immaturity of the CYP450 oxidation system [15, 46, 49, 51] and the larger relative liver volume found in children [59] but these theoretical mechanisms have not been confirmed
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