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Direct estimates were derived from head-to-head trials, while indirect estimates were obtained through a common comparator across the included trials

Originally developed to treat type 2 diabetes and later approved for conditions like obesity and sleep apnea, these medications are now being touted by influencers and researchers alike for their potential as longevity drugs. Notably, a growing cohort of health professionals has been examining the potential impact of GLP-1s on longevity markers, such as cholesterol and glucose levels, which can shed light on overall health

The addition of glucagon receptor activation increases energy expenditure and fat oxidation beyond what GLP-1 alone can achieve

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