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Furthermore, single-nucleotide polymorphisms XBP1 in patients with vitiligo illuminate the importance of this pathway in the pathogenesis of vitiligo ( 5 Nrf2 Antioxidant response pathway Oxidative stress is considered as a major event in vitiligo pathogenesis (Figure 2A)

171 Taken together, these findings illustrate that phytochemicals, such as flavonoids (galangin, SKN), terpenoids (triptolide), phenolic acids (canolol, CGA), and polyphenols, act as potent antioxidants in the GI tract

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