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However, these are often transient and manageable with dose adjustments
If you experience any suspected side effects from any medicine licensed or otherwise you can report these to the MHRA via the Yellow Card Scheme at yellowcard.mhra.gov.uk
These medications, including the Wegovy pill that was approved in December 2025, are reshaping how obesity is treated, offering powerful tools when combined with lifestyle changes
Please contact your doctor ASAP and seek in-person care immediately if a side effect becomes problematic or you experience: Severe nausea and/or vomiting resulting in dehydration- it is important to stay well hydrated and drink plenty of fluids while on this medication Kidney problems/kidney failure - vomiting, nausea, diarrhea can cause dehydration and kidney issues and make kidney problems worse in individuals who have pre-existing kidney conditions
Development of Melanotan I and II The initial compound developed was known as Melanotan I (afamelanotide)
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