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Preclinical studies have demonstrated no significant toxicity even at doses far exceeding therapeutic ranges
During severe infections, plasma vitamin C levels can become rapidly depleted, which is why injection therapy has been studied in critically ill patients
Most patients start at 300 mcg/day and titrate toward 500 mcg/day
Do not double-dose to compensate
For those looking at peptide alternatives, tesofensine and 5-amino-1MQ offer different mechanisms of action
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