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However, its relationship with arthroplasty timing remains complex, and available evidence does not yet define an optimal interval between bariatric surgery and joint replacement ( Other anti-obesity medications may also be considered according to efficacy, contraindications, tolerability, availability, and cost

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This illustrates how trial protocols treat missed dosing not only as a logistical matter but also as a methodological one: too many lapses can compromise both safety and statistical validity

2.2 Hepatic Impairment Study 2.2.1 Study Population Male and female participants of non-childbearing potential aged between 18 and 80 years with a BMI between 18.5 and 39.9 kg/m 2 were eligible for inclusion in the hepatic impairment study