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"And through a wonderful series of discussions with the sponsor, with a very compelling reason, we decided to take eventscardiovascular death and worsening heart failure eventsand take it out of the composite and have it as a standalone end point." Packer added that worsening heart failure events were adjudicated by a blinded end point committee and defined as worsening symptoms of heart failure requiring either hospitalization, urgent intravenous drug therapy, or oral diuretic intensification
The OASIS 4 trial showed 13.6% mean weight loss (16.6% with full adherence) at 64 weeks for oral semaglutide 25 mg
While the inflammation-reducing and fibrosis-attenuating effects of glucagon agonism are less well-characterized, the reductions in hepatic inflammation parameters and fibrosis observed in preclinical models likely reflect secondary effects consequent to improved steatosis, rather than direct anti-inflammatory actions [21]
A Multi-Center, Open-Label, Phase I Study of Single Agent RG7112: A First in Class p53-MDM2 Antagonist, in Patients with Relapsed/Refractory Acute Myeloid and Lymphoid Leukemias (AML/ALL) and Refractory Chronic Lymphocitic Leukemia/Small Cell Lymphocytic Lymphomas (CLL/SCLL)