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Our finding of similar incidence of non-fatal cardiovascular outcomes with GLP1-RA compared to DPP4i is in line with the recently published FLOW study that randomized people with early to mid-stage CKD to semaglutide or placebo, which reported similar incidence of non-fatal myocardial infarction and non-fatal stroke across the semaglutide and placebo treated groups, despite a significantly reduced risk of major kidney disease events and all-cause death 44

GLP-1RA intervention was not associated with a reduction in fasting glucose level when compared to those given metformin or placebo (MD = 0.12

Research involving PDA (BPC-157-Arginine) continues to evolve, and additional human studies are needed

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