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PARP inhibitors like rucaparib induce mitochondrial fragmentation via Ca 2+ /CaMKII/Drp1 signaling, suggesting potential synergy with mitochondrial destabilizers (Arbini et al., 2013)
Neurological abnormalities, along with visual and hearing impairments, have been described in children with CFD
2023;71(6):1414-1428 Alanko V
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Insulin-like functions can increase lipolysis and reduce lipid storage in the liver ( Exendin-4 can also regulate the transcription of several miRNAs and reduce steatosis in HepG2 cells (W et al., 2022)
