1g) (compared with Gipr AP-GFP mice), RER, energy expenditure or ambulatory activity, as measured in metabolic cages (Extended Data Fig
1B-1C and Fig
[6] Proposed mechanisms for cardiovascular benefits of incretin-based therapies include: Vascular effects : Improved endothelial function and reduced arterial stiffness Anti-inflammatory actions : Decreased systemic inflammation and oxidative stress Metabolic improvements : Enhanced insulin sensitivity and reduced hepatic glucose production Hemodynamic changes : Blood pressure reduction, though with modest increases in heart rate Renal protection : Reduced albuminuria and preservation of kidney function The cardiovascular benefits appear partially independent of weight loss itself, suggesting potential cardioprotective properties of incretin pathway activation
For starters, it offers faster absorption by delivering nutrients directly into your bloodstream, bypassing your digestive system entirely (a big plus if antibiotics have been rough on your gut)
Interestingly, previous transcriptional analysis uncovered that AITC treatment affected the expression profile of certain genes involved in the regulation of cell cycle 23 , indicating the phytochemical-induced growth inhibition might be an indirect consequence of cell cycle misregulation due to GSH depletion